Abcam, ab194356, Anti-MYO1B antibody [EPR16223]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MYO1B antibody. Suitable for WB, IHC-P and reacts with Mouse, Human, Rat samples. Cited in 13 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16223,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MYO1B also known as Myosin IB belongs to the myosin superfamily. It weighs approximately 123 kDa. MYO1B functions as an actin-binding protein with ATPase activity contributing to cellular processes like membrane tension and transport. This protein is expressed in various tissues including brain intestines and kidneys. It plays a role in dynamic cellular environments where it influences membrane dynamics and trafficking.
Biological function summary
MYO1B participates in cellular processes by associating with actin filaments. MYO1B contributes to vesicular transport and cell cortex regulation. It acts as a monomer and does not form complexes with other myosins. MYO1B's ability to interact with plasma membrane and microfilaments facilitates movement and stabilization tasks essential for maintaining cellular structure and function.
Pathways
MYO1B interacts with dynamic cellular events involving actin remodeling and intracellular transport. The protein plays roles in the actin cytoskeleton pathway and is linked to the regulation of endocytosis. MYO1B interacts with proteins like actin and other myosins which support its functions within the pathways and ensure effective cellular responses to environmental cues.
Researchers have associated MYO1B with conditions like deafness and some cancers. The protein's influence on cell membrane dynamics and movement may link it to hearing-related disorders. Its dysregulation or alterations can affect cellular behavior contributing to tumorigenic pathways. In cancer research MYO1B interacts with proteins such as cadherins showing potential pathways that can be important in disease progression and therapy targets.