Abcam, ab194362, Anti-FBXO40 antibody [EPR15005-34]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal FBXO40 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15005-34,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FBXO40 also known as F-box only protein 40 is a member of the F-box protein family which is characterized by containing an approximately 40 amino acid motif known as the F-box. It has a mass of around 48 kDa. Mechanically FBXO40 functions as part of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex targeting specific proteins for ubiquitination and subsequent proteasomal degradation. This protein embeds itself within skeletal muscle tissue where its expression plays an essential role.
Biological function summary
FBXO40 regulates muscle protein turnover and influences muscle mass maintenance. As part of a ubiquitin ligase complex FBXO40 participates actively in marking proteins for degradation which is essential for cellular homeostasis. The regulation of signaling molecules involved in muscle physiology makes FBXO40 an important player in maintaining muscle integrity and function. The activity of FBXO40 can indirectly affect muscle growth and the adaptation of muscle tissue to various physiological conditions.
Pathways
FBXO40 engages in the ubiquitin-proteasome system which is critical for protein quality control and cellular regulation. It works alongside other proteins like SKP1 in the SCF complex which targets specific proteins for degradation ensuring proper protein balance within the cell. The interaction with pathways involving skeletal muscle differentiation and remodeling highlights its role in the precise regulation of cellular signaling mechanisms important for muscle development and function.
Research indicates that FBXO40 may associate with muscular dystrophies characterised by the progressive weakening of muscle mass. It is particularly implicated in the pathology of conditions that affect muscle protein breakdown and synthesis. FBXO40 has also been connected with proteins such as myostatin which inhibit muscle growth suggesting a potential link between disrupted FBXO40 function and muscle-related disorders. The understanding of FBXO40's role could contribute to the development of therapeutic strategies addressing genetic muscle diseases.