Abcam, ab194448, Anti-EYA1 antibody

Size: 50µL
Mouse Polyclonal EYA1 antibody. Suitable for WB and reacts with Recombinant fragment - Human, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EYA1 aa 100-200.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EYA1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q99502

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The EYA1 protein known as Eyes Absent Homolog 1 acts as a transcriptional coactivator and tyrosine phosphatase. It has a molecular weight of approximately 65 kDa. EYA1 expresses in various tissues including the kidney eye and branchial arches during developmental stages. It plays essential roles in organogenesis by modulating gene expression via its interaction with other proteins.
Biological function summary
EYA1 contributes significantly to the formation of several organs during embryonic development. This protein is part of the EYA-SIX transcriptional complex and works closely with SIX family proteins to regulate the expression of multiple key developmental genes. Through its phosphatase activity EYA1 also affects phosphorylated protein substrates altering their function and stability.
Pathways
EYA1 plays an important role in the regulation of the WNT and SHH signaling pathways both of which are fundamental for embryonic development and cell differentiation. EYA1 interacts with related proteins like SIX1 aiding in the transcriptional regulation needed for cellular proliferation and differentiation. Interferences in these pathways can lead to developmental anomalies.
Mutations or dysregulation of EYA1 have links to conditions such as Branchio-Oto-Renal (BOR) syndrome and congenital cataracts. The association with BOR syndrome arises from EYA1's interaction with other related proteins including SIX1 that regulate the development of the ear kidney and certain facial structures. EYA1's role in ocular development also connects it to certain types of hereditary cataracts demonstrating its impact on normal physiological processes when mutated.