Abcam, ab194826, Anti-MRPL48 antibody [EPR16328]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MRPL48 antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16328,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, Flow Cyt (Intra), WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRPL48 also known as mitochondrial ribosomal protein L48 is a component of the mitochondrial ribosome. This protein has a mass of approximately 18.7 kDa and plays a role in protein synthesis within mitochondria. MRPL48 locates itself mostly in the mitochondria of cells across various tissues with higher expression levels observed in tissues with high energy demands such as muscle and liver.
Biological function summary
MRPL48 contributes to the formation and function of the mitochondrial ribosome which is responsible for synthesizing proteins that are essential for mitochondrial respiration and energy production. This protein is part of the large subunit of the mitochondrial ribosome which includes many other mitochondrial ribosomal proteins. Together they form a complex responsible for translating mitochondrial mRNA into functional proteins.
Pathways
MRPL48 is actively engaged in mitochondrial translation a critical pathway for maintaining mitochondrial function and energy production. In this pathway it associates with other mitochondrial ribosomal proteins to produce enzymes necessary for the electron transport chain and ATP synthesis. MRPL48 also relates to oxidative phosphorylation where it plays a part in generating cellular energy linking it to proteins such as cytochrome c oxidase subunit IV.
Defects in MRPL48 could relate to mitochondrial dysfunctions which may contribute to disorders like mitochondrial myopathy and mitochondrial complex I deficiency. These conditions often manifest muscle weakness neurological problems and metabolic disturbances. In these disorders MRPL48's interaction with other mitochondrial ribosomal proteins is important as impaired mitochondrial protein synthesis can cause decreased energy production and increased oxidative stress within cells.