Abcam, ab194828, Anti-MYO1C antibody [EPR14771]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MYO1C antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Mouse, Rat, Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14771,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MYO1C also known as myosin IC is involved in intracellular transport. It works as a molecular motor that converts chemical energy into mechanical work playing a fundamental role in cellular processes. MYO1C has a molecular mass of approximately 122 kDa. It is ubiquitously expressed found in various tissues with a significant presence in the inner ear and kidneys and also in adipose tissue and platelets.
Biological function summary
The actions of MYO1C affect cellular movement and signal transduction. It cooperates with actin filaments forming part of the cytoskeletal complex. This complex aids in maintaining cellular shape and facilitating endocytosis and exocytosis. MYO1C's role is significant in cellular adaptation to stimuli and is part of chromatin dynamics influencing transcription regulation.
Pathways
MYO1C interacts with several key biological processes. It is notably involved in the insulin signaling pathway where it directly affects glucose uptake and metabolism. MYO1C also plays a part in the auditory signaling pathway contributing to hearing processes. Important related proteins in these pathways include actin which it closely associates with and GLUT4 a critical protein for glucose transport.
MYO1C's dysfunction can lead to certain health issues. It has been linked to hearing impairments as it plays a role in auditory function. Additionally MYO1C is relevant in metabolic disorders such as insulin resistance due to its involvement with insulin signaling. The protein is indirectly connected with MLCK which affects muscle function and insulin response in these contexts.