Abcam, ab194941, Anti-RIC8A antibody

Size: 100µg
Rabbit Polyclonal RIC8A antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RIC8A aa 400-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RIC8A aa 400-500. The exact immunogen used to generate this antibody is proprietary information.Q9NPQ8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RIC8A also known as Synembryn-A is a guanine nucleotide exchange factor that plays an important mechanical role in cellular signaling. It catalyzes the exchange of GDP for GTP on G protein alpha subunits activating them. RIC8A weighs approximately 60 kDa and is mainly cytoplasmic. Researchers have identified its expression in several tissues such as the brain heart and lungs indicating a wide pattern of activity in the body.
Biological function summary
RIC8A is involved in intracellular signaling and regulation of G-protein coupled receptor (GPCR) pathways. It does not directly form part of a stable complex but interacts transiently with heterotrimeric G proteins during activation. Through these interactions RIC8A influences processes such as neurotransmitter release cell division and hormone secretion. It also affects synaptic signals and is important for proper brain function.
Pathways
RIC8A plays a significant role in the Wnt signaling and synaptic transmission pathways. It operates by interacting with GPCR-related proteins like G-alpha subunits which are coupled later to downstream effectors. In the Wnt signaling pathway RIC8A supports signal propagation critical for cell fate determination. The synaptic transmission pathway further benefits from RIC8A's role in modulating neurotransmitter release making it essential for neural communication.
Researchers have linked RIC8A dysfunction to various neurological disorders and cancer. Abnormal RIC8A function can contribute to conditions like epilepsy and certain types of tumor growth owing to its role in cell signaling and division. The interaction of RIC8A with proteins like G-alpha subunits and components of the Wnt signaling pathway highlights its involvement in these diseases. Such associations suggest potential therapeutic target opportunities for addressing these complex conditions.