Abcam, ab195312, Anti-JP-1 antibody

Size: 100µg
Rabbit Polyclonal JP-1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human JPH1 aa 450-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human JPH1 aa 450-500. The exact immunogen used to generate this antibody is proprietary information.Q9HDC5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JP-1 also known as Jump-1 protein functions mechanically as a mediator in cellular signal transduction processes. It comprises a mass of approximately 50 kilodaltons and is mainly expressed in the brain and heart tissues. JP-1 exhibits a capability for facilitating interactions between membrane-receptor proteins and intracellular signaling molecules playing a part in modulating various cellular responses.
Biological function summary
This protein plays roles beyond signal transduction contributing to cellular homeostasis and stress responses. JP-1 often associates with other protein complexes within the cell enhancing its regulatory capacity. JP-1's interactions influence processes like cell growth and apoptosis impacting overall cellular stability.
Pathways
JP-1 has connections with the MAPK/ERK pathway and the PI3K/Akt pathway. These pathways are significant for cell proliferation differentiation and survival. Within these signaling routes JP-1 interacts closely with proteins such as Raf-1 in the MAPK/ERK pathway and Akt in the PI3K/Akt pathway assisting in the precise modulation of these signaling cascades.
JP-1 shows associations with neurodegenerative diseases and heart disorders. Researchers observed alterations in JP-1 expression levels in conditions like Alzheimer's disease where it may interact with amyloid precursor proteins. In cardiac diseases it links with proteins involved in cardiac stress responses indicating its potential role in these pathological processes.