Abcam, ab195329, Anti-RUNX1T1/ETO/CDR antibody - ChIP Grade

Size: 100µL
Rabbit Polyclonal RUNX1T1/ETO/CDR antibody. Suitable for ChIP and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human RUNX1T1 aa 250-300 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ChIPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.Synthetic Peptide within Human RUNX1T1 aa 50-100 conjugated to Keyhole Limpet Haemocyanin. Database linkQ06455

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Preservative: 0.05% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RUNX1T1 also known as ETO or CDR is an important transcriptional regulator. It has a mass of approximately 70 kDa. This protein is expressed in various body tissues including hematopoietic cells. RUNX1T1 is heavily involved in transcriptional repression playing a role in chromatin remodeling and gene expression regulation. Structurally it binds to DNA through specific interactions which influences gene activation or repression contributing to the regulation of cell differentiation.
Biological function summary
The functions of RUNX1T1 involve its participation in the formation of transcriptional complexes. It interacts with several co-repressors and co-activators affecting gene transcription which is important for hematopoiesis. It regulates a range of gene expressions minimally necessary for normal blood cell development. These complexes enable RUNX1T1 to function in a tightly controlled way supporting tissue-specific gene expression and ensuring balance in cell proliferation and differentiation.
Pathways
RUNX1T1 has pivotal roles in the hematopoietic and differentiation pathways. It interacts with RUNX1 forming a RUNX1-RUNX1T1 fusion that disrupts normal blood cell development. This fusion alters its typical role in the regulation of gene transcription which intersects with other signaling pathways such as the TGF-beta pathway. RUNX1T1-ETO fusion is linked with important proteins involved in signaling and transcription processes which demonstrate its broad relevance within cellular growth pathways.
RUNX1T1's misregulation or fusion with RUNX1 characterizes certain leukemias notably acute myeloid leukemia (AML). This fusion protein acts aberrantly in hematopoiesis contributing to the development of leukemic cells. Apart from leukemia abnormalities in RUNX1T1 function can also impact other disorders related with defects in blood cell development. The disease association highlights RUNX1T1's interaction with other oncogenic proteins like FLT3 influencing AML pathogenesis.