Abcam, ab195334, Anti-KRAP antibody

Size: 100µg
Rabbit Polyclonal KRAP antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ITPRID2 aa 1200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ITPRID2 aa 1200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P28290

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab195334 was affinity purified using an epitope specific to KRAP immobilized on a solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KRAP also known as Ki-ras-induced actin-interacting protein is an important target in cell biology. This protein has a mass of approximately 128 kDa and is expressed in various tissues including the liver kidney and colon. It often interacts with cellular components to influence their structures and functions. In these tissues KRAP localizes to the cytoskeletal and membrane compartments playing a role in maintaining cellular integrity.
Biological function summary
KRAP contributes significantly to cellular function regulation by modulating GTPase activity and calcium ion signaling. It functions as part of a complex that includes proteins related to actin filament dynamics and signal transduction. Through these interactions KRAP influences processes such as cell shape and motility. This highlights its role in cytoskeletal organization and intracellular signaling pathways essential for normal cellular operations.
Pathways
KRAP has important involvement in the Rho family GTPase signaling and calcium signaling pathways. These pathways are integral to various cellular processes including cell migration division and differentiation. KRAP interacts closely with proteins like Rac1 and Cdc42 which are key players in cytoskeletal reorganization and signal relay. Such interactions underline its significance in facilitating cellular responses to external and internal cues.
KRAP's malfunction can relate to conditions like cancer and neurodegenerative diseases. Abnormal expression or regulation of KRAP affects cell structure and signaling leading to tumorigenesis or degeneration. KRAP also connects to proteins such as Ras and amyloid-beta in these diseases linking its structural and signaling roles to pathologies. Understanding its role could guide strategies for therapeutic intervention or disease management.