Abcam, ab196024, Anti-RABL3 antibody [EPR16709] - C-terminal

Size: 10µL-TRIAL / 100µL / 1mL
Rabbit Recombinant Monoclonal RABL3 antibody. C-terminal. Suitable for WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16709,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RABL3 also known as Rab-like protein 3 is a member of the Rab-like small GTPase family. It has a molecular mass of approximately 28 kDa. RABL3 plays a central role in cellular trafficking and transport by acting as a molecular switch cycling between an active GTP-bound state and an inactive GDP-bound state. Expression of RABL3 is widespread across various tissues although its exact expression pattern may vary depending on the cell type and physiological condition.
Biological function summary
RABL3 functions in the regulation of intracellular signaling pathways. It associates with other molecular partners to influence the dynamics of cargo transport through vesicles. While it is not specifically identified as part of a larger complex its interactions with other small GTPases suggest a collaborative role in vesicle docking and fusion processes. RABL3's function impacts cell communication and signal transduction vital processes in maintaining cellular homeostasis and response to environmental signals.
Pathways
RABL3 engages in the RAS signaling pathway where it may regulate downstream effects of RAS activation. In particular it can interact with proteins like RAB6 and RABL2 which share similar roles in vesicular trafficking and transport. The RAS signaling pathway's influence in growth and metabolism provides insight into RABL3's potential to modulate signal transduction efficiency and cellular response mechanisms.
Defects in RABL3 are associated with certain forms of cancer and neurodegenerative disorders. Its involvement is particularly noted in its connection to the KRAS protein which is significantly implicated in oncogenic transformations. Alterations in RABL3 expression or function may disrupt normal cellular signaling and transport contributing to disease progression. Understanding these interactions can help target therapeutic strategies for conditions related to these dysregulated pathways.