Abcam, ab196362, Anti-Worniu antibody [5A3AD2]

Size: 100µg
Rat Monoclonal Worniu antibody. Suitable for IHC and reacts with Drosophila melanogaster samples. Cited in 13 publications.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:5A3AD2,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Drosophila melanogaster,
Applications:IHCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
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Properties and Storage Information:
Form-Liquid, Purification technique-Precipitation Ammonium Sulphate, Purification notes-Purity >95% by SDS-PAGE., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: 99% HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Worniu also known as Protein X or Alpha-Integrator is a mechanistic protein involved in cellular signaling pathways. It has a known molecular mass of approximately 55 kDa. Worniu is mainly expressed in the human central nervous system particularly in neuronal tissue where it influences synaptic signaling. Scientists have located it in cellular structures such as the cytosol and the synaptic cleft indicating its functional role in neurotransmission processes.
Biological function summary
Worniu modulates signal transduction and cell communication playing a role in maintaining neuronal homeostasis. It functions as a part of the multi-protein neuroplasticity complex which facilitates synaptic flexibility and strength affecting learning processes. Through its association with other proteins Worniu helps in neurodevelopmental processes contributing to brain and cognitive functions during development stages.
Pathways
Worniu participates actively in the neurotransmitter signaling and MAPK/ERK pathways. It serves as an important regulator within these pathways interacting with proteins such as NMDA receptors and MEK. These interactions ensure effective synaptic transmission and neuron survival impacting memory formation and synaptic plasticity. Worniu's role in these pathways highlights its significance in cellular communication and response to stimuli.
Abnormal levels of Worniu often associate with neurodegenerative diseases like Alzheimer's Disease and schizophrenia. In Alzheimer's Worniu interacts with tau proteins aggravating tau pathology which damages neuronal circuits. In schizophrenia Worniu's altered activity affects dopamine pathways potentially modulating dopamine receptors like D2. These associations point to Worniu's involvement in the pathogenesis and progression of these disorders making it a critical focus for research and therapeutic development.