Abcam, ab196552, Anti-SLC3A1 antibody

Size: 100µL
Rabbit Polyclonal SLC3A1 antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC3A1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC3A1. The exact immunogen used to generate this antibody is proprietary information.Q07837

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SLC3A1 protein also known as rBAT (related to basic amino acid transport) is a transporter protein that plays an important role in the transport of amino acids across cell membranes. It functions as a heavy chain subunit with a molecular mass of approximately 68 kDa. SLC3A1 is highly expressed in the kidney particularly within the proximal tubules and is also present in other tissues like the intestine. It partners with a light chain subunit to facilitate the uptake of cystine and dibasic amino acids.
Biological function summary
SLC3A1 is integral to the reabsorption of cystine and dibasic amino acids in renal and intestinal epithelial cells. It is a part of the cystine-dibasic amino acid transporter complex functioning alongside the light chain protein SLC7A9. This interaction ensures the effective transport of key molecules necessary for maintaining amino acid homeostasis within the body. By forming a dimer with SLC7A9 SLC3A1 helps regulate amino acid flux essential for normal cell function and metabolism.
Pathways
SLC3A1 is actively involved in amino acid transport pathways particularly those specialized in neutral and dibasic amino acids. It is linked to the cysteine and methionine metabolism pathway where its activity ensures the prevention of cystine accumulation. The protein associates with SLC7A9 and other members of the solute carrier family facilitating various metabolic and transport processes that affect cellular nutrient balance.
SLC3A1 mutations are related to a condition known as cystinuria a genetic disorder that leads to the formation of cystine stones in the kidneys. This connection is significant as malfunction of SLC3A1 disrupts cystine reabsorption causing excessive cystine in urine. The protein SLC7A9 is frequently connected with SLC3A1 in this disorder reflecting their partnership in amino acid transport. Understanding this relationship helps in the development of targeted treatments for cystinuria and related metabolic disruptions.