Abcam, ab196623, Anti-PSMB1 antibody

Size: 100µL
Rabbit Polyclonal PSB1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PSMB1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human PSMB1.P20618

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PSMB1 also known as proteasome subunit beta type-1 or XAPC7 plays an important role in the proteasome a multicatalytic proteinase complex. The molecular weight of PSMB1 is approximately 26 kDa. PSMB1 expression occurs in various tissues suggesting its wide involvement in cellular processes. This subunit contributes to the proteolytic activity of the 20S core within the proteasome facilitating protein degradation which is essential for maintaining cellular homeostasis.
Biological function summary
PSMB1 functions as part of the proteasome's 20S core particle. This complex is responsible for most of the protein degradation in cells particularly targeting misfolded or damaged proteins for ubiquitin-mediated proteolysis. The breakdown of proteins is essential for cellular processes like cell cycle regulation and response to oxidative stress. PSMB1 also helps in the processing of antigens for presentation on MHC class I molecules influencing immune surveillance.
Pathways
PSMB1 involvement is significant in the ubiquitin-proteasome pathway a central pathway in protein catabolism. This pathway enables the cell to control protein levels and quality interacting closely with proteins such as ubiquitin and other proteasome subunits like PSMC2 or PSMA3. Additionally PSMB1 contributes to the regulation of the NF-kB signaling pathway which is important for immune and inflammatory responses by degrading inhibitors that keep NF-kB inactive.
PSMB1 has connections with cancer and neurodegenerative diseases like Alzheimer’s. Its role in protein degradation impacts the accumulation of dysfunctional proteins that characterize these diseases. Overexpression or mutation of PSMB1 may affect its interaction with other proteins like beta-amyloid in Alzheimer's or oncogenes in cancer which can lead to pathological states. Understanding PSMB1's function can aid in developing therapeutic strategies targeting proteostasis-related disorders.