Abcam, ab196675, Anti-Anoctamin 7 antibody - C-terminal

Size: 100µL
Rabbit Polyclonal Anoctamin 7 antibody. C-terminal. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ANO7.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ANO7. The exact immunogen used to generate this antibody is proprietary information.Q6IWH7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab196675 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Anoctamin 7 also known as ANO7 or TMEM16G is a transmembrane protein that belongs to the anoctamin family. It functions as a calcium-activated chloride channel with a role in ion transport. Anoctamin 7 has a molecular weight of approximately 120 kDa. The protein is expressed in many tissues with high levels in the prostate suggesting a specialized function in this organ.
Biological function summary
ANO7 influences important cellular processes like fluid secretion cell volume regulation and signal transduction. It is a component of a larger protein complex involved in calcium signaling which impacts various physiological functions. In the prostate ANO7 expression may influence normal prostate function and development indicating a possible role in prostate-specific tasks.
Pathways
ANO7 participates in important pathways like calcium-dependent regulation of ion transport and signal transduction through chloride channels. It interacts with proteins such as ANO1 and ANO2 within these pathways sharing similar chloride channel functions. These interactions are necessary for maintaining ion balance and signaling across cell membranes impacting general cellular homeostasis.
ANO7's expression has been linked to prostate cancer where abnormalities in its function may influence disease development or progression. The protein is also associated with disorders related to ion transport potentially due to its role in chloride channel regulation. Research on ANO7 interactions with other proteins like ANO1 might reveal further insights into its contribution to these conditions.