Abcam, ab196761, Anti-JIP3 antibody

Size: 100µL
Rabbit Polyclonal JIP3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human MAPK8IP3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MAPK8IP3. The exact immunogen used to generate this antibody is proprietary information.Q9UPT6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JIP3 also known as c-jun-amino-terminal kinase-interacting protein 3 or MAPK8IP3 is a scaffold protein with a molecular mass of approximately 150 kDa. It mediates intracellular signaling pathways and facilitates interactions between kinases and their substrates. JIP3 predominantly localizes in the cytoplasm and expresses highly in the brain especially in neurons. This protein plays a role in axonal transport and cytoskeletal organization.
Biological function summary
JIP3 influences neuronal signaling and development processes. It acts as a scaffold in kinase cascades particularly within the JNK signaling pathway forming complexes with JNK and other MAP kinases. The protein ensures proper localization and docking of kinases promoting efficient signal transduction. JIP3 links signaling components thereby influencing processes like neuronal migration and polarization.
Pathways
JIP3 serves as a significant component in the JNK and p38 MAPK pathways. These pathways are important for regulating cellular responses to stress apoptosis and immune responses. Within these pathways JIP3 interacts with JNK and other associated proteins like MAPK8 facilitating proper signaling flow. JIP3's function as a molecular scaffold coordinates cellular events through these signal transduction pathways.
JIP3 connects to neurodegenerative diseases such as Alzheimer’s and Amyotrophic Lateral Sclerosis (ALS). Dysregulation in the JNK signaling pathway often links to these conditions. Additionally disturbed axonal transport involving JIP3 can contribute to such neurodegenerative disorders. The relationship of JIP3 with other proteins like tau in Alzheimer’s further highlights the involvement of JIP3 in disease pathogenesis.