Abcam, ab196791, Anti-PPRC1 antibody

Size: 100µL
Rabbit Polyclonal PPRC1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PPRC1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PPRC1. The exact immunogen used to generate this antibody is proprietary information.Q5VV67

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab196791 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PPRC1 also known as Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a transcriptional coactivator protein. It has an approximate mass of 166 kDa. Researchers have found it expressed in various tissues notably in skeletal muscle and heart tissue. PPRC1 interacts with other proteins to regulate gene expression linked to metabolic processes.
Biological function summary
PPRC1 functions in cellular energy metabolism regulation. It forms part of a larger transcriptional complex where it interacts with PGC-1 family members including PGC-1α. PPRC1 plays an important role in mitochondrial biogenesis by coactivating nuclear receptors. It regulates the expression of genes associated with oxidative metabolism impacting cellular energy production and expenditure.
Pathways
PPRC1 engages in the mitochondrial biogenesis and oxidative phosphorylation pathways. These pathways are critical for energy metabolism in cells. PPRC1 interacts closely with PGC-1α and NRF1 partners that are essential for upregulating mitochondrial and respiratory chain genes. These interactions enhance the capacity for aerobic energy production and are important for cellular adaptation to energetic demands.
PPRC1 is associated with conditions linked to mitochondrial dysfunction and metabolic syndromes. Dysregulation of PPRC1 can contribute to diseases like type 2 diabetes and obesity. PGC-1α often partners with PPRC1 in these disorders affecting the expression of genes involved in glucose and lipid metabolism. Understanding PPRC1’s role offers insights into therapeutic targets for treating these metabolic conditions.