Abcam, ab197021, Anti-NUDT9 antibody [EPR15175]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NUDT9 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15175,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:Flow Cyt (Intra), WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NUDT9 also known as Nudix Hydrolase 9 is an enzyme that exhibits pyrophosphatase activity on molecules like ADP-ribose. It has an approximate mass of 35 kDa. NUDT9 is expressed in various tissues with significant levels observed in the brain and heart. This protein helps break down ADP-ribose into AMP and ribose-5-phosphate assisting in the regulation of cellular ADP-ribose concentrations.
Biological function summary
NUDT9 helps to maintain cellular balance by controlling levels of ADP-ribose a substrate for poly ADP-ribose polymerases. This regulation is essential for energy metabolism and DNA repair processes. NUDT9 operates independently and does not blend into larger protein complexes focusing strictly on its enzymatic role ensuring the cell's homeostasis.
Pathways
NUDT9 is significantly involved in NAD+ metabolism and the DNA repair mechanism. By converting ADP-ribose NUDT9 interacts with pathways that are central to maintaining cellular energy balance and protecting cells from DNA damage. It is functionally linked with enzymes such as PARP (poly ADP-ribose polymerase) which are pivotal in detecting and signaling DNA strand breaks.
NUDT9's role in regulating ADP-ribose links it to conditions where cellular stress and energy metabolism are disrupted. Its malfunction has correlations with neurodegenerative diseases like Alzheimer's where altered energy metabolism and DNA damage responses are critical factors. NUDT9 also connects with proteins like PARP which are implicated in this pathological context indicating a potential therapeutic target for managing such disorders.