Abcam, ab197029, Anti-ODF1 antibody [EPR15496]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ODF1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15496,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ODF1 also known as Outer Dense Fiber Protein 1 plays an important role in the structural integrity of sperm flagella. The protein has a molecular mass of approximately 29 kDa. It localizes particularly to the outer dense fibers of sperm cells an important site for motility. Expression of ODF1 occurs primarily in the testis especially in mature spermatozoa where it contributes to the stability and function of the sperm tail.
Biological function summary
ODF1 contributes significantly to sperm motility and structural support within the sperm flagellum. As part of more complex structures ODF1 interacts with other potential flagellar components to ensure adequate mechanical support during sperm movement. By providing this stability ODF1 enables sperm cells to withstand the mechanical forces they encounter in the reproductive tract which is essential for male fertility.
Pathways
Several critical molecular interactions link ODF1 to reproductive success and sperm motility. Notably it plays a role within the sperm motility pathway and is interconnected with other structural proteins such as AKAP3 (A-Kinase Anchoring Protein 3) to provide anchoring points and scaffolding within the sperm tail. These pathways maintain proper structural function which is important for efficient motility and fertility.
Dysfunction or mutations in ODF1 may lead to male fertility issues such as asthenozoospermia characterized by reduced sperm motility. Research suggests a potential interaction with related proteins such as SPAG16 (Sperm Associated Antigen 16) which may further influence motility and structural integrity. Understanding these relationships can help in creating targeted therapies and diagnostics for reproductive health.