Abcam, ab197070, Anti-MEF2A + MEF2C antibody [EPR19089-34]

Size: 100µL / 1mL
Anti-MEF2A + MEF2C antibody [EPR19089-34] (ab197070) is a rabbit monoclonal antibody detecting MEF2A in Western Blot, Flow Cytometry (Intra), Flow Cytometry, IHC-P, ICC/IF . Suitable for Human, Mouse, Rat . - KO validated for confirmed specificity - Biophysical QC for unrivalled batch-batch consistency - Over 10 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19089-34,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-MEF2A + MEF2C antibody [EPR19089-34] (ab197070) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples.
What is the molecular weight of MEF2A?
Anti-MEF2A + MEF2C [EPR19089-34] (ab197070) specifically detects a band for MEF2A (UniProt: Q06413) at a molecular weight of 51kDa.
Trusted by the scientific community
Anti-MEF2A + MEF2C [EPR19089-34] (ab197070) was first used in a scientific publication in 2015 and has been cited over 10 times in peer-reviewed journals.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Specificity confirmed
The specificity of Anti-MEF2A + MEF2C antibody [EPR19089-34] (ab197070) has been confirmed by Western blot testing in MEF2C Knockout THP-1 cell line,
ab313739
Other related products
We have a range of other formats of antibody clone [EPR19089-34] also available for your convenience: ab197070, Carrier free -
ab238446
, Carrier free -
ab282242
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MEF2A (Myocyte Enhancer Factor 2A) and MEF2C (Myocyte Enhancer Factor 2C) are transcription factors belonging to the MEF2 family. MEF2A has a molecular mass of approximately 55 kDa while MEF2C is around 51 kDa. Both MEF2A and MEF2C modulate gene expression through direct binding to regulatory DNA sequences. These proteins express in numerous tissues including muscle brain and vascular tissues indicating their extensive role in various cellular processes. MEF2A and MEF2C closely relate due to their structural similarities and functional overlap often working in concert with similar cofactors and regulatory proteins.
Biological function summary
MEF2A and MEF2C regulate multiple cellular processes especially in muscle differentiation and neuronal development. They frequently form complexes with other transcriptional regulators and play a significant role in the activation and repression of target genes. Through their interaction with the regulatory regions of DNA they help coordinate the transcriptional response necessary for cell growth development and survival. Their important involvement in muscle and nervous system development positions them as central players in maintaining proper cellular function during these processes.
Pathways
MEF2A and MEF2C serve as integral components in the MAPK and calcium signaling pathways. These pathways impact cellular response to environmental stimuli and regulate critical processes such as cell growth and differentiation. Interacting proteins like HDACs (histone deacetylases) further modulate the activity of MEF2A and MEF2C affecting their ability to regulate gene expression in response to various signals. This relationship is essential because it sustains the balance between activation and repression of target genes within these pathways.
MEF2A and MEF2C have significant implications in cardiovascular diseases and neurological disorders. Mutations or dysregulation in MEF2A often link to coronary artery disease highlighting its importance in cardiovascular health. Meanwhile MEF2C plays a role in autism spectrum disorders with abnormalities in its expression or function disrupting normal neuronal development. Both MEF2A and MEF2C interact with proteins such as GATA4 in the context of cardiac function and synaptic proteins for neuronal development respectively providing potential therapeutic targets for addressing the associated diseases and disorders.