Abcam, ab197808, Anti-ACOX2 antibody

Size: 100µL
Rabbit Polyclonal ACOX2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Fusion protein corresponding to Peroxisomal acyl-coenzyme A oxidase 2, fused to Peroxisomal acyl-coenzyme A oxidase 2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Fusion protein corresponding to Peroxisomal acyl-coenzyme A oxidase 2, fused to Peroxisomal acyl-coenzyme A oxidase 2. The exact immunogen used to generate this antibody is proprietary information.Q99424

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACOX2 also known as acyl-CoA oxidase 2 or branched-chain acyl-CoA oxidase plays an important role in fatty acid metabolism. This enzyme weighs about 75 kDa and resides in the peroxisomes. It catalyzes the initial step in the peroxisomal beta-oxidation pathway of branched-chain fatty acids. ACOX2 expression can be detected in various tissues including the liver and kidneys where its metabolic functions are essential.
Biological function summary
The ACOX2 protein is responsible for the oxidation of long and very-long-chain fatty acids. Its activity serves as the first step in their catabolism contributing to lipid homeostasis. While ACOX2 functions as a monomer it operates in conjunction with other enzymes facilitating the breakdown of branched-chain fatty acids into simpler molecules for energy production and management of lipid derivatives within the body.
Pathways
ACOX2 functions in the peroxisomal beta-oxidation pathway and fatty acid degradation pathway. These pathways oversee the breakdown of branched-chain fatty acids and other non-standard fatty acids. ACOX2's activity relates to other proteins like ACOX1 and peroxisomal enzyme complexes which carry out subsequent steps in fatty acid oxidation. Through these pathways ACOX2 maintains energy balance and lipid regulation at the cellular level.
ACOX2 has been linked to metabolic disorders and peroxisomal biogenesis defects such as Zellweger syndrome. Mutations or deficiencies in ACOX2 can result in the buildup of branched-chain fatty acids leading to metabolic disruptions. Additionally disorders like X-linked adrenoleukodystrophy may involve related enzymes such as ACOX1 which share similar pathways and contribute to the disease etiology.