Abcam, ab198261, Anti-PDP1/PDP antibody

Size: 100µL
Rabbit Polyclonal PDP1/PDP antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PDP1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PDP1. The exact immunogen used to generate this antibody is proprietary information.Q9P0J1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The pyruvate dehydrogenase phosphatase 1 (PDP1) is a mitochondrial enzyme that regulates the activity of the pyruvate dehydrogenase complex by dephosphorylating its E1 component. Also known as PDPc PDP1 has a molecular mass of approximately 56 kDa. Expression of PDP1 occurs in various tissues but shows higher levels in heart and skeletal muscles. These tissues demand efficient energy production correlating with PDP1's role in energy metabolism.
Biological function summary
PDP1 plays an essential role in converting pyruvate to acetyl-CoA a substrate for the Krebs cycle. PDP1 is part of the pyruvate dehydrogenase complex a multi-enzyme complex important for linking glycolysis to the citric acid cycle. This regulation ensures that cells can respond effectively to the energetic needs and environmental conditions optimizing production of ATP from glucose.
Pathways
PDP1 is involved in key metabolic pathways like the citric acid cycle and glucose metabolism. In glucose metabolism PDP1 interacts with pyruvate dehydrogenase kinase (PDK) as both enzymes control the phosphorylation state of the pyruvate dehydrogenase complex. This dynamic balance affects the availability of acetyl-CoA and thereby influences cellular respiration and energy production.
Malfunction of PDP1 associates with metabolic disorders such as pyruvate dehydrogenase deficiency and lactic acidosis. Mutations or dysregulations in PDP1 can disrupt acetyl-CoA production and lead to energy metabolism defects. The relationship between PDP1 and PDK also plays a role in understanding these conditions as both enzymes affect how well the cells manage energy impacting overall metabolic homeostasis.