Abcam, ab198502, Anti-LIM2 antibody [EPR16947]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal LIM2 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16947,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The LIM2 protein also known as lens intrinsic membrane protein 2 is a lens-specific protein with a molecular mass of approximately 22 kDa. It is part of the eye lens fiber cells and is critical in maintaining lens transparency and structural integrity. LIM2 is highly expressed in the lens contributing to its function in the eye.
Biological function summary
LIM2 plays a significant role in lens development and homeostasis. It is part of the integral membrane proteins that influence lens fiber cell maturation and intercellular communication. LIM2 interacts with other cellular components supporting the structural arrangement necessary for proper lens function.
Pathways
LIM2 participates in cell adhesion and signal transduction pathways in the eye lens. These pathways are essential for maintaining cell shape transparency and communication within lens cells. LIM2 functions in concert with proteins like connexins which are also integral to cell-cell communication within the lens.
Mutations in the LIM2 gene have been linked to cataracts and other lens-related abnormalities. These conditions often result from disruptions in lens transparency and refractive properties that LIM2 helps maintain. The alpha crystallin and gamma crystallin proteins are related to LIM2 as their interactions affect lens clarity and structure contributing to cataract formation when dysfunctional.