Abcam, ab198801, Anti-IFN gamma Receptor beta/AF-1 antibody

Size: 100µL
Rabbit Polyclonal IFN gamma Receptor beta/AF-1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human IFNGR2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human IFNGR2. The exact immunogen used to generate this antibody is proprietary information.P38484

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The IFN gamma Receptor beta also known as IFN-γ receptor β chain or IFN gamma receptor AF-1 plays a significant role in the immune response. This receptor is part of the interferon gamma receptor complex which binds the cytokine IFN-gamma. The beta chain contributes to the formation of the receptor complex that allows functional IFN-gamma signaling. Typically the receptor is expressed on the surface of immune cells like lymphocytes and macrophages facilitating communication and response to infections and immune challenges. The exact molecular mass can vary depending on glycosylation often giving an approximate mass of 35-50 kDa.
Biological function summary
IFN gamma Receptor beta is essential for the activation of the immune system. It partners with IFN gamma Receptor alpha in the receptor complex to mediate important biological effects such as activation of macrophages and enhancement of antigen presentation. This activity boosts the cellular immune response allowing cells to better combat microbial infections and tumor growth. Without functional receptor activity cells would not effectively respond to IFN-gamma signals impeding proper immune function.
Pathways
IFN gamma Receptor beta is involved in the JAK-STAT signaling pathway which is important for mediating IFN-gamma signaling. Once IFN-gamma binds to its receptor including the beta chain it triggers the activation of JAK kinases which in turn phosphorylates STAT1. Phosphorylated STAT1 dimerizes translocates to the nucleus and influences the expression of immune regulatory genes. This pathway connects the receptor with key immune regulatory proteins playing an important role in the immune response.
IFN gamma Receptor beta is associated with conditions such as chronic granulomatous disease and various mycobacterial infections. These conditions often result from immune system malfunctions where the receptor cannot properly signal IFN-gamma activity leading to an impaired defense against pathogens. The involvement of the receptor in immune pathways links it to other critical proteins like IFN gamma Receptor alpha and STAT1 both of which might be implicated in IFN-gamma-related dysfunctions contributing to these diseases.