Abcam, ab198977, Anti-CGBP antibody [EPR19199] - ChIP Grade

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CGBP antibody. Suitable for IP, ChIP, WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat samples. Cited in 8 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19199,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, IHC-P, ChIP, IP, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CGBP also known as CpG-binding protein is a DNA-binding protein with a mass of about 66 kDa. It is recognized for its function in binding to unmethylated CpG motifs in DNA. Scientists have observed its expression mainly in the nucleus where it plays a significant role in regulating gene expression. The interaction with these CpG regions is essential for maintaining gene activity and stability.
Biological function summary
CGBP influences the transcriptional regulation by acting as a transcription factor. This protein is part of a complex that includes other regulatory proteins assisting in the activation of specific gene sets. It participates by directing the cellular signals that modulate chromatin structure impacting the transcriptional landscape of several genes.
Pathways
CGBP interacts with cellular mechanisms that involve DNA methylation and histone modification. It is integrated within pathways like the Wnt signaling pathway and is related to proteins such as DNMT1 which is important for DNA methylation processes. This interaction supports its role in modulating gene silencing and activation across different cellular contexts.
Scientists have linked CGBP to cancer and autoimmune diseases. Alterations in CGBP expression or function can disrupt normal epigenetic regulation contributing to oncogenesis and immune dysregulation. In cancer its interaction with DNMT1 further associates it with aberrant methylation patterns a hallmark of many tumors. Similarly dysregulation of CGBP can influence pathways leading to autoimmune conditions complicating immune cell homeostasis.