Abcam, ab199086, Alexa Fluor® 488 Anti-alpha + beta Synuclein antibody [EP1646Y]

Size: 100µL
Rabbit Recombinant Monoclonal Alpha-synuclein antibody - conjugated to Alexa Fluor® 488. Suitable for ICC/IF and reacts with Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1646Y,
Isotype:IgG,
Conjugation:Alexa Fluor® 488,
Excitation/Emission:Ex: 495nm, Em: 519nm,
Carrier free:No,
Reacts with:Rat,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Alpha-synuclein and beta-synuclein are proteins implicated in the dynamics of neuronal function. Alpha-synuclein also known as SNCA is a synaptic protein weighing approximately 14 kDa expressed highly in the central nervous system. Unlike alpha-synuclein beta-synuclein shares a similar structure but differs in function and molecular weight. Both proteins belong to the synuclein family which also includes gamma-synuclein and are found primarily in pre-synaptic terminals contributing to synaptic vesicle physiology.
Biological function summary
Alpha- and beta-synuclein play roles in synaptic function and plasticity where they influence neurotransmitter release and vesicle recycling. These proteins do not generally form a stable complex with each other but their presence together suggests a regulatory interplay. Alpha-synuclein may promote vesicle formation and trafficking while beta-synuclein appears to counteract alpha's effects potentially protecting neurons from alpha-synuclein aggregation.
Pathways
Alpha- and beta-synuclein are key components in the synaptic vesicle cycle especially associated with the SNARE complex and neurotransmitter balance. Alpha-synuclein interacts with proteins like VAMP2 and STX1A in vesicle merging while beta-synuclein's regulatory role has implications in maintaining these interactions. In lipid metabolism alpha-synuclein influences fatty acid binding protein pathways impacting neuronal lipid transport and homeostasis.
Alpha- and beta-synuclein hold significant relevance particularly in neurodegenerative disorders like Parkinson's disease and dementia with Lewy bodies which show marked alpha-synuclein aggregates known as Lewy bodies. Alpha-synuclein's accumulation in neurons correlates with disease progression. Beta-synuclein on the other hand appears to have a protective role potentially mitigating the toxicity of alpha's aggregates. The relation between these synucleins underlines their importance in therapeutic research for these disorders.