Abcam, ab199104, Anti-mAKAP antibody

Size: 100µL
Rabbit Polyclonal mAKAP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human AKAP6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human AKAP6. The exact immunogen used to generate this antibody is proprietary information.Q13023

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MAKAP also known as muscle A-kinase anchoring protein plays an important role in cellular signaling by anchoring protein kinase A (PKA) and other signaling proteins. It has a molecular weight of approximately 250 kDa. mAKAP is primarily expressed in striated muscle tissues including cardiac and skeletal muscles. Its localization within the cell is important for its function as it coordinates the activity of various signaling molecules in response to external and internal stimuli.
Biological function summary
MAKAP facilitates the integration of cyclic adenosine monophosphate (cAMP)-dependent signaling pathways by anchoring PKA and phosphodiesterases (PDEs) within signaling complexes. It organizes these complexes at the perinuclear region and other cellular sites ensuring precise signaling. By supporting the assembly of these molecular components mAKAP regulates processes such as contractility and hypertrophy in cardiac muscle.
Pathways
MAKAP acts as a scaffold that coordinates the cAMP and calcium signaling pathways which are critical in cardiac muscle function. It interacts with PKA and PDEs to finely tune the signaling cascades that control heartbeats and muscle contraction. Furthermore mAKAP has a functional relationship with the small GTPase Ras integrating signaling inputs that modulate cell cycle and growth responses.
MAKAP has been implicated in cardiac diseases particularly in heart failure and cardiac hypertrophy. Its role in organizing signaling complexes contributes to maladaptive cardiac remodeling. mAKAP interacts with calcineurin a protein involved in cardiac hypertrophy suggesting its potential involvement in pathological conditions. Research indicates that disruptions in mAKAP-regulated signaling pathways could maladaptively affect cardiac physiology emphasizing its role in disease mechanisms.