Abcam, ab199177, Anti-GPR182 antibody - Membrane Vesicle Marker

Size: 100µL
Rabbit Polyclonal GPR182 antibody. Membrane Vesicle marker. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GPR182.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GPR182. The exact immunogen used to generate this antibody is proprietary information.O15218

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR182 also known by the alternate name adenylate cyclase inhibitory G protein-coupled receptor is a transmembrane protein weighing approximately 45 kDa. It belongs to the family of G protein-coupled receptors (GPCRs) which possess seven transmembrane domains. GPR182 is widely expressed in tissues such as the heart liver and kidney. Its expression suggests a role in various physiological processes where it might interact with other molecules across cellular membranes.
Biological function summary
GPR182 influences cellular signaling by potentially regulating cyclic AMP (cAMP) levels. This receptor does not appear to form part of a larger protein complex but operates independently in signal transduction. Its signaling activity might affect processes such as cell growth and differentiation which could imply roles in development and response to external signals. Through these processes GPR182 contributes to maintaining cellular homeostasis.
Pathways
GPR182 engages in pathways that regulate cAMP production. This engagement links it to the G protein signaling pathway important for transmitting signals from hormones and neurotransmitters. Related proteins in this pathway include the adenylate cyclases which produce cAMP and other GPCRs involved in similar signaling roles. These connections help modulate different physiological responses demonstrating the importance of GPR182 in cellular communication networks.
GPR182 shows relevance to cardiovascular disease and cancer. Its expression and function imply roles in growth and repair processes of cardiovascular tissues. In cancer GPR182 might interact with proteins like beta-catenin influencing cell proliferation and metastasis. These interactions suggest GPR182 as a potential target for therapeutic strategies aiming to regulate abnormal signaling and contribute to disease management.