Abcam, ab199426, Anti-TIAM2 antibody [EPR16838]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TIAM2 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Mouse, Rat, Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16838,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TIAM2 also known as T-cell lymphoma invasion and metastasis 2 is a guanine nucleotide exchange factor (GEF) with a mass of approximately 180 kDa. It plays a significant role mechanically by activating the small GTPase Rac1 leading to changes in actin cytoskeleton organization. This protein localizes in the cytoplasm and shows expression in many tissues but finds higher levels in the brain and lymphoid organs. Its role extends to cellular processes like cell migration proliferation and adhesion.
Biological function summary
TIAM2 contributes to intracellular signaling that governs cell shape and movement. It participates as part of a larger signaling complex that includes other GEFs and scaffold proteins. By facilitating the switch of Rac1 from inactive GDP-bound state to active GTP-bound state TIAM2 influences pathways that control the dynamics of the actin cytoskeleton important for cellular structural change highlighting its importance in the development of cellular architecture and motility.
Pathways
TIAM2 activates signaling cascades related to cell migration and differentiation. It plays an essential role in the Rac1-PAK pathway which regulates the actin cytoskeleton dynamics. This pathway interconnects with other signaling molecules like CDC42 and PAK kinases creating a network that controls cellular responses and contacts with the extracellular matrix. In this network TIAM2 acts as a facilitator for cellular adaptation to environmental stimuli.
TIAM2 links to conditions such as cancer metastasis and neurological disorders. Alterations in its expression or function contribute to the progression of certain cancers by promoting increased motility and invasive capabilities of tumor cells. Additionally abnormalities in TIAM2 activity have been observed in diseases like schizophrenia where it interacts with proteins such as DISC1 affecting neuronal signaling and stability. Understanding TIAM2's involvement in these diseases provides insight into therapeutic targets for managing disease progression.