Abcam, ab199528, Anti-NUP155 antibody [EPR17111]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal NUP155 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17111,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NUP155 is a nucleoporin a component of the nuclear pore complex that regulates nucleocytoplasmic transport. Its mass is approximately 155 kDa. The protein is prominently expressed in tissues with high cellular activity like the liver and pancreas as it assists in managing the transport needs of these metabolically active areas. NUP155 facilitates the exchange of molecules between the nucleus and the cytoplasm playing a significant role in cellular communication.
Biological function summary
This nucleoporin is essential in maintaining the structure and function of the nuclear envelope. NUP155 is part of the extensive nuclear pore complex which consists of multiple proteins working together to manage the transport of RNA and proteins across the nuclear envelope. NUP155 acts as a scaffold that helps maintain the integrity of this complex ensuring the proper exchange between nuclear and cytoplasmic compartments vital for gene regulation and expression.
Pathways
NUP155 participates in pathways like nucleocytoplasmic transport and cell cycle regulation. It interacts with other nuclear pore proteins such as NUP93 and NUP205 to coordinate the import and export of macromolecules. In the cell cycle pathway NUP155 ensures proper mitotic progression by managing the transport of regulatory proteins necessary for cell division.
Alterations in NUP155 function have associations with cardiac arrhythmias and certain types of cancers. In arrhythmias NUP155 mutations disrupt cellular signaling processes affecting cardiac rhythm regulation. Linked with tumorigenesis abnormal NUP155 expression can alter nucleocytoplasmic transport contributing to cancer development. Its interactions with other proteins like NUP93 may offer insights into therapeutic targets for these conditions.