Abcam, ab199531, Anti-PMF-1 antibody [EPR17298]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PMF-1 antibody. Suitable for WB, IP and reacts with Rat, Mouse, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17298,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PMF-1 also recognized as Polyamine-modulated factor 1 is a protein with a molecular mass of around 63 kDa. It plays a mechanical role in transcriptional regulation by interacting with other proteins and DNA sequences. PMF-1 is expressed mainly in the nucleus of cells across various tissues. It partners with other transcription factors modulating gene expression essential for cellular growth and differentiation. This interaction underlines its importance in transcriptional control.
Biological function summary
PMF-1 engages in modifying transcriptional responses by forming part of the TCF/LEF transcription factor complex. This complex influences the expression of genes involved in cellular proliferation and differentiation. PMF-1 functions by binding to specific DNA sequences enhancing or repressing the transcription of target genes. Through these actions it serves as a regulatory hub for controlling numerous cellular responses including but not limited to cell cycle progression and apoptosis.
Pathways
PMF-1 interacts significantly within the Wnt signaling pathway. This pathway is pivotal for regulating cellular processes related to development and growth. PMF-1 associates with proteins such as β-catenin facilitating the transcriptional activation of Wnt target genes. Through this pathway PMF-1 helps transmit signals that dictate cellular fate decisions illustrating its importance in maintaining physiological balance.
PMF-1 has notable implications in cancer and neurodegenerative conditions. In cancer its association with the Wnt signaling pathway implies roles in cell proliferation and tumor progression. The interaction with β-catenin further solidifies its connection to oncogenic processes. In neurodegenerative disorders altered PMF-1 activity can influence neuronal growth and survival implicating it in pathologies like Alzheimer's disease through dysregulated transcriptional responses.