Abcam, ab200049, Anti-Aldolase + Aldolase C antibody [EPR19355] - Astrocyte Marker

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Aldolase antibody. Astrocyte marker. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Recombinant full length protein - Human, Mouse, Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19355,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt (Intra), ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Aldolase C also known as fructose-bisphosphate aldolase C is a glycolytic enzyme involved in the conversion of fructose-16-bisphosphate into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. This enzyme belongs to the class I aldolase family and shares high sequence similarity with aldolase A and aldolase B. The molecular weight of aldolase C is approximately 39 kDa. It is mainly found in the brain particularly in the cerebellum where it plays important roles in metabolic processes.
Biological function summary
Aldolase C functions in the glycolytic pathway an important metabolic pathway for producing energy. While it does not form part of a larger protein complex aldolase C interacts with other proteins involved in metabolic flux regulation. It contributes to maintaining glucose homeostasis in neural tissues by ensuring efficient glucose metabolism. In comparison the related aldolase A enzyme is expressed in muscle and has distinct functions related to muscle energy metabolism.
Pathways
Aldolase C plays a significant role in the glycolytic and gluconeogenesis pathways. In glycolysis it catalyzes a critical step that ensures continuous energy supply to brain tissues. Gluconeogenesis serves to create glucose from non-carbohydrate sources. Aldolase C's relationship with other glycolytic enzymes like hexokinase and pyruvate kinase enhances the coordination of energy metabolism pathways predominantly within neurons.
Aldolase C alterations have links to neurodegenerative diseases such as Alzheimer's disease and cerebellar ataxia. In Alzheimer’s disease aberrant metabolic processes in the brain may involve dysregulation of aldolase C's function altering energy metabolism. Scientists have observed altered aldolase C expression in cerebellar ataxia a disorder characterized by the degeneration of cerebellar cells. Changes in aldolase C activity might also interact with other neurodegeneration-related proteins like tau contributing further to disease pathology.