Abcam, ab200370, Anti-ASB2 antibody

Size: 100µL
Rabbit Polyclonal ASB2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ASB2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ASB2. The exact immunogen used to generate this antibody is proprietary information.Q96Q27

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ASB2 also known as ankyrin repeat and SOCS box-containing protein 2 plays a role mechanically as part of the E3 ubiquitin ligase complex. It facilitates the tagging of proteins for degradation via the ubiquitin-proteasome system. ASB2 has a molecular mass of approximately 57 kDa and exhibits robust expression in hematopoietic cells particularly within the bone marrow.
Biological function summary
ASB2 modulates cellular differentiation and it is often associated with lineage determination in hematopoietic cells. As a component of the ubiquitin ligase complex it performs a critical role in regulating protein stability by promoting ubiquitination. ASB2 interacts with several cellular proteins and contributes to the balance of protein degradation ensuring proper cell function and responses to various stimuli.
Pathways
ASB2 integrates into ubiquitin-mediated proteolysis and hematopoietic cell development pathways. It affects protein turnover and modulates signaling pathways essential for cell cycle regulation. The ASB2 protein interacts with others such as substrates in the ubiquitination process contributing to maintaining cellular homeostasis and promoting normal cellular activities.
ASB2 connections emerge in leukemia and anemia where its dysregulation impacts disease progression. In leukemia altered ASB2 expression disrupts normal cell differentiation suggesting a role in malignant transformation. This protein also associates with components of the proteolysis pathway implicating faulty protein degradation processes in anemia. Understanding ASB2 interactions may provide insights into therapeutic approaches for these conditions.