Abcam, ab201227, Anti-AP3M1 antibody [EPR16385]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal AP3M1 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16385,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The immunogen used for this product（ab201227） shares 78% homologue with AP3M2. (AP-3 complex subunit mu-2). Cross-reactivity with this protein has not been confirmed experimentally.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AP3M1 also known as AP-3 complex subunit mu is an important component of the adaptor protein 3 (AP-3) complex. It has a molecular weight of approximately 46 kilodaltons. This protein is expressed in various tissues including neuronal and immune cells indicating its wide-reaching roles in cellular functions. AP3M1 participates actively in cargo recognition and vesicle formation playing a substantial role in the transport and sorting of membrane proteins to specialized compartments within cells.
Biological function summary
The AP3M1 protein integrates into the adaptor protein 3 (AP-3) complex which is important for the trafficking of lysosomal membrane proteins. AP3M1 contributes to assembly and stabilization of the AP-3 complex facilitating the recruitment of clathrin and membrane-bound receptors. This indicates the protein's essential role in the maintenance of cellular homeostasis and intracellular protein traffic impacting the delivery of proteins necessary for lysosomal function and integrity.
Pathways
AP3M1 finds importance in the endosomal-lysosomal pathway and is connected to various cellular processes that manage degradation and recycling of cellular materials. This protein collaborates with other AP-3 complex subunits such as AP3B1 to ensure proper lysosome-related organelles biogenesis. Furthermore AP3M1 intersects with the BLOC-1 (biogenesis of lysosomal organelles complex 1) pathway highlighting its involvement in trafficking and organelle organization specifically in melanosomes and platelet dense granules.
AP3M1 has associations with Hermansky-Pudlak syndrome type 2 and immunodeficiencies. Mutations affecting the AP3M1 function can lead to pigmentary anomalies and immunological defects related to improper lysosomal trafficking. The dysfunction of AP3M1 alongside AP3B1 illustrates its critical role in these diseases as both contribute to the effective formation and function of lysosome-related organelles.