Abcam, ab201305, Anti-RAB41 antibody

Size: 100µL
Rabbit Polyclonal RAB41 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RAB41 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RAB41 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q5JT25

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purity is > 95% (by SDS-PAGE)., Storage buffer-pH: 7.3Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RAB41 also known as Ras-related protein Rab-41 is a member of the Rab family of GTPases and plays a critical role in the regulation of vesicular trafficking. This protein has a mass of approximately 25 kDa. RAB41 exerts its mechanical functions by cycling between an active GTP-bound form and an inactive GDP-bound form. It is expressed in various tissues with notable expression in brain liver and lung tissues. Its localization suggests diverse roles in different cellular compartments particularly in the early stages of the Golgi apparatus.
Biological function summary
The Ras-related protein Rab family member 41 engages in intracellular vesicle transport processes and the maintenance of Golgi integrity. It interacts with other proteins as part of a complex that facilitates the proper sorting and delivery of proteins and lipids throughout the cell. RAB41 involvement is essential in the formation and trafficking of Golgi-derived vesicles impacting cellular functions like protein secretion membrane protein localization and recycling pathways.
Pathways
Vesicle-mediated transport and the secretory pathway are major systems involving RAB41. In these pathways RAB41 associates with other proteins such as Coatomer Protein Complex I (COPI) and is instrumental in the retrograde vesicle transport from the Golgi to the endoplasmic reticulum. This involvement highlights its significance in maintaining proper cellular homeostasis and efficient cargo delivery and recycling within the cell.
Abnormal RAB41 function has been implicated in cancer and neurodegenerative diseases. Altered expression or mutation may contribute to the progression of cancer by disrupting normal vesicle transport and cellular communication. Additionally RAB41 dysfunction relates to neurodegenerative disorders through its connection with proteins like Tau which are important in maintaining neuronal health. Understanding these relationships can aid in developing therapeutic targets for related diseases.