Abcam, ab201326, Anti-Homeobox protein prospero antibody [P3D4-1F10]

Size: 100µg
Rat Monoclonal Protein S antibody. Suitable for ICC/IF and reacts with Drosophila melanogaster samples. Cited in 1 publication.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:P3D4-1F10,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Drosophila melanogaster,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
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Properties and Storage Information:
Form-Liquid, Purification notes-Purity: 97.2%, Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: 99% HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Homeobox protein prospero also known as Prox1 is a transcription factor involved in regulating gene expression. Common alternate names for this protein include mR1a and ah1-1. It consists of around 83 kDa in its full-length form. The protein is present in various tissues most notably in the nervous system retina and lymphatic endothelium. In these locations homeobox protein prospero influences cell differentiation and growth by modulating the activity of specific target genes.
Biological function summary
Homeobox protein prospero plays a significant role in neural development influencing the fate and proliferation of neural stem cells. It acts within the nucleus where it binds consensus DNA sequences to control gene transcription. This protein does not usually operate as part of a large complex instead it often interacts directly with chromatin to exert its effects. Its activity is essential for normal neurogenesis and the formation of functional neural circuits.
Pathways
Homeobox protein prospero is essential for the Hedgehog signaling pathway which is critical in the regulation of stem cell maintenance and differentiation. It works closely with other transcription factors such as Pax6 to ensure proper development of the nervous system. Additionally it is involved in the Wnt signaling pathway where it synergizes with other factors to control cell proliferation and fate determination in developing tissues.
Defects or dysregulation of homeobox protein prospero have links to various cancers including medulloblastoma and colorectal cancer. Changes in its expression levels can impact the growth and spread of these cancers. The protein has connections with other proteins like β-catenin within cancer pathways emphasizing its importance in tumor progression events. Studies also associate mutations in this protein with eye disorders like aniridia where Pax6 also plays a contributory role highlighting potential genetic interactions affecting eye development and health.