Abcam, ab201454, Anti-RPS8 antibody [EPR17334]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal RPS8 antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17334,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt (Intra), WB, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ribosomal protein S8 (RPS8) also known as S8 is a component of the small 40S subunit of the eukaryotic ribosome. This protein has a mass of approximately 20 kDa and is widely expressed in most tissues reflecting its fundamental role in cellular processes. RPS8 belongs to the ribosomal protein S8P family and plays a mechanical role in the assembly and function of the ribosome where it contributes to protein synthesis by facilitating mRNA translation.
Biological function summary
Ribosomal protein S8 is fundamental in translation an essential cellular process that translates mRNA sequences into polypeptide chains. As part of the ribosomal 40S subunit RPS8 aids in the initiation of translation by interacting with other ribosomal proteins and rRNA to form a functional ribosome. This subunit along with the 60S large subunit comprises the active ribosome complex engaged in translating genetic information into the proteome.
Pathways
RPS8 is involved in the protein synthesis pathway a critical driver of cellular proliferation and metabolism. It participates actively in the mRNA surveillance pathway ensuring the efficiency and accuracy of translation. It interacts with other proteins such as RPS6 and RPS14 which are also constituents of the small ribosomal subunit acting synergistically to regulate the efficacy of the translation process. Moreover RPS8 involvement in the ribosome biogenesis pathway emphasizes its integral role in cellular growth and division.
Alterations in ribosomal protein S8 are connected to ribosomopathies a group of disorders characterized by defective ribosome function. Dysregulation or mutations in RPS8 can lead to Diamond-Blackfan anemia a rare congenital disorder causing impaired erythropoiesis. Additionally RPS8 has correlations with cancer where aberrant expression levels contribute to tumorigenesis. In cancer RPS8 might interact with oncogenic proteins such as MYC heightening the proliferative potential of cancer cells.