Abcam, ab20169, Anti-HLA B7 antibody [BB7.1]

Size: 50µg
Mouse Monoclonal HLA B antibody. Suitable for Flow Cyt and reacts with Human, Monkey samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Human HLA-B.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:BB7.1,
Isotype:IgG1,
Light chain type:unknown,
Carrier free:No,
Reacts with:Human, Monkey,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Full Length Protein corresponding to Human HLA-B. The exact immunogen used to generate this antibody is proprietary information.P01889

Product details:
Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). This antibody can be used for HLA typing.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HLA-B7 also known as HL-A B7 is a part of the human leukocyte antigen (HLA) system and belongs to the HLA class I heavy chain paralogs. This protein has a molecular mass of approximately 45 kDa. HLA-B7 is expressed on the surface of nearly all nucleated cells in the body. Its main role is to present peptide antigens to the immune system specifically to cytotoxic T cells which play an important part in immune response.
Biological function summary
HLA-B7 is involved in antigen presentation as a part of the major histocompatibility complex (MHC) class I molecule. HLA-B7 like other HLA class I molecules presents endogenous peptides to CD8+ T cells. The HLA B27 pair although different from HLA-B7 shares functional similarities that influence immune surveillance and activation processes.
Pathways
HLA-B7 participates in the antigen processing and presentation pathway. This pathway allows the presentation of intracellularly derived peptides at the cell surface which are recognized by T cell receptors (TCR) on CD8+ T lymphocytes. HLA-B7 works in concert with proteasomes for peptide generation and with transporter associated with antigen processing (TAP) for delivering peptides to the endoplasmic reticulum.
HLA-B7 is linked with certain autoimmune diseases and viral infections. Some studies suggest an association with increased susceptibility to diseases such as sarcoidosis. Moreover individuals who are HLA-B7 positive may differ in their immune response to viral infections like HIV. The interaction between HLA-B7 and proteins like beta-2 microglobulin further affects its role in disease mechanisms and immune function.