Abcam, ab201920, Anti-Neuron navigator 1 antibody [KT124]

Size: 100µg
Rat Monoclonal Neuron navigator 1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NAV1 aa 700-1050.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:KT124,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NAV1 aa 700-1050. The exact immunogen used to generate this antibody is proprietary information.Q8NEY1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-ab201920 is purified from culture supernatant using a protein G column., Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neuron navigator 1 often known as NAV1 is a protein involved in axonal guidance with a molecular weight approximately 200 kDa. It plays a role in the development of the nervous system where it aids in the navigation of growing axons. NAV1 is expressed mainly in the central nervous system showing a high presence in the brain especially in regions relating to emotional and cognitive functions.
Biological function summary
Neuron navigator 1 assists in the transduction of signals required for guiding axons to their correct destinations during neural development. Though not part of a specific complex NAV1 interacts with microtubules exerting influence on the stability and organization of the cytoskeleton within neurons. This interaction underpins its role in regulating the direction and rate of axonal growth.
Pathways
Neuron navigator 1 engages in neural development pathways and cytoskeletal organization. It functions alongside proteins like LIS1 and DCX which are involved in controlling the structure and dynamics of microtubules. Through these pathways NAV1 contributes to the precise navigation and guidance of neuronal projections impacting both embryonic neural patterning and mature neural circuitry.
Neuron navigator 1 has been associated with neurodevelopmental conditions like autism spectrum disorders and intellectual disability. Disruptions in NAV1 function can lead to impaired axonal guidance which may contribute to aberrant neural circuitry seen in these disorders. In the context of these conditions proteins such as reelin have been implicated which aids in proper layering of neurons during brain development suggesting possible interactions or parallel disruptions involving NAV1.