Abcam, ab202057, Anti-REG3A + REG3G antibody [EPRR18188]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal REG3A antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human, Recombinant fragment samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPRR18188,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
REG3A also known as regenerating islet-derived protein 3 alpha and REG3G also known as regenerating islet-derived protein 3 gamma are small secretory proteins with molecular weights around 19 kDa. They are expressed mostly in the pancreas and gut epithelium. REG3A and REG3G contribute to the immune defense of the gastrointestinal tract. Their expression increases in response to inflammation and microbial presence acting as antimicrobial proteins that contribute to maintaining gut microbiota balance.
Biological function summary
Regenerating islet-derived proteins promote epithelial cell survival and are important in the mucosal immune response. Though not part of a larger complex these proteins bind to bacterial cell walls and disrupt their integrity causing lysis. They also recruit immune cells to sites of injury assisting in tissue repair. This ability highlights their role in coordinating the innate immune response within the gut.
Pathways
REG3A and REG3G participate in the intestinal innate immune pathways where they enhance host defense mechanisms against bacterial infections. They are interrelated with the Toll-like receptor signaling pathway which helps detect microbial patterns and initiate immune responses. REG3 proteins work in conjunction with other antimicrobial peptides to amplify the intestinal immune defense and contribute to regulation of inflammatory responses.
Both proteins associate with inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Increased levels of REG3A and REG3G occur in patients with these disorders indicating their possible involvement in mucosal inflammation and host-pathogen interactions. Their expression links to cytokines such as IL-22 and IL-17 which are upregulated during inflammatory responses suggesting that REG3 proteins might act in modulating pathways that sustain chronic inflammation in gut-related diseases.