Abcam, ab202123, Anti-Gastrin Releasing Peptide antibody

Size: 100µL
Rabbit Polyclonal GRP antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Gastrin-releasing peptide.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Gastrin-releasing peptide.P07492

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Gastrin-Releasing Peptide (GRP) also known as the bombesin-like peptide is a 27-amino acid peptide with a molecular mass of approximately 3 kDa. GRP is synthesized in the gastrointestinal tract where it plays a role in the regulation of gastric acid secretion and gut motility. It is also expressed in the central nervous system especially in regions associated with sensory and autonomic functions. The peptide's expression in neuroendocrine cells further signifies its involvement in neurotransmitter and hormone release.
Biological function summary
GRP functions in stimulating the release of gastrin a hormone that promotes gastric acid secretion and mucosal growth. It does not act in isolation; instead GRP often forms part of a neuropeptide network that influences gastric functions and energy metabolism. Additionally it modulates inflammatory responses and cellular communication in tissues where it is active. This diverse range of functions highlights the peptide's role in maintaining physiological balance.
Pathways
The gastrin-releasing peptide engages primarily in the gastrin-related pathways which involve gastric acid secretion. GRP acts upstream of the pathway by binding to its receptor the GRP receptor (GRPR) promoting the release of gastrin from G cells. Interaction with other proteins in this system such as cholecystokinin and secretin help regulate digestive functions. Additionally GRP is a part of the signaling pathways that influence the release of insulin and other hormones that are pivotal to digestive efficiency.
GRP has associations with certain cancers like prostate cancer and small cell lung cancer where it acts as an autocrine growth factor. These cancers often show elevated levels of GRP suggesting its role in cancer cell proliferation. Furthermore higher levels of GRP may link to inflammatory bowel disease as it modulates immune and inflammatory responses in the gut. In these contexts GRP interacts with proteins involved in tumorigenesis and inflammation providing potential targets for therapeutic intervention.