Abcam, ab202283, Anti-SMCR8 antibody

Size: 100µg
Rabbit Polyclonal SMCR8 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human SMCR8 aa 600-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SMCR8 aa 600-650. The exact immunogen used to generate this antibody is proprietary information.Q8TEV9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab202283 was affinity purified using an epitope specific to SMCR8 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SMCR8 also known as Smith-Magenis Syndrome Chromosome Region 8 is a protein with a molecular weight of approximately 105 kDa. This protein is expressed in multiple tissues with significant presence in the brain kidney and liver. SMCR8 functions mechanically as a guanine nucleotide exchange factor and it plays a vital role in cellular homeostasis and autophagy.
Biological function summary
SMCR8 is involved in regulating macroautophagy a critical process for cellular maintenance by forming a complex with the C9orf72 protein. This complex ensures proper lysosomal positioning and function impacting the cell's ability to remove damaged organelles and proteins. SMCR8’s activity is essential for maintaining normal lysosomal dynamics and preventing the accumulation of toxic substances within the cell.
Pathways
SMCR8 participates in the autophagy and lysosome pathways. It interacts with several other proteins including UVRAG and Beclin1 which are important for autophagosome formation and maturation. SMCR8 and its associated pathways are important in coordinating proper cellular degradation and recycling processes ensuring cellular stability and function.
SMCR8 has been connected to neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations or dysfunction in SMCR8 can interfere with autophagy contributing to the pathogenesis of these disorders. The interaction between SMCR8 and C9orf72 has been particularly highlighted in relation to ALS as disruptions in this interaction could aggravate disease progression.