Abcam, ab202560, Anti-PCDH15 antibody [EPR19600]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PCDH15 antibody. Suitable for WB, ICC/IF and reacts with Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19600,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PCDH15 also known as Protocadherin-15 is a protein encoded by the PCDH15 gene. Mechanically this protein functions as an adhesion molecule in the body playing an important role in cell-cell interactions. PCDH15 has a molecular mass of approximately 223 kDa. It has a widespread expression but is particularly found in sensory cells in the inner ear and in the retina of the eye highlighting its importance in sensory functions.
Biological function summary
PCDH15 participates in the formation of tip-link structures within the inner ear. This protein is a component of the mechanotransduction complex which translates mechanical stimuli into electrical signals. PCDH15 works alongside other proteins like Cadherin 23 another protocadherin to maintain the integrity of hair cells. Its role is essential for proper auditory and visual signal processing contributing to the sense of hearing and vision.
Pathways
PCDH15 interacts with the mechanotransduction pathway in sensory cells. This pathway plays a role in converting mechanical stimuli such as sound waves in the cochlea into nerve impulses. Cadherin 23 is closely related in this pathway and together these proteins maintain the hair cell structure necessary for mechanotransduction. The interplay between these proteins ensures the transduction of sensory information impacting cellular responses in sensory organs.
PCDH15 mutations associate with Usher syndrome type 1F and non-syndromic hearing loss. Usher syndrome is a genetic condition involving hearing loss and vision impairment. PCDH15 mutations disrupt the mechanotransduction complex affecting sensory perception. Cadherin 23 also connects to these disorders as mutations in this protein can similarly lead to issues in hearing and vision. Understanding PCDH15 and its interactors is critical in addressing these sensory disorders.