Abcam, ab203298, Anti-Adenosine A3 Receptor/A3AR antibody

Size: 100µL
Rabbit Polyclonal Adenosine A3 Receptor/A3AR antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 9 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Adenosine A3 Receptor (A3AR) also known as A3 adenosine receptor is a member of the G-protein-coupled receptor family. This receptor couples with Gi proteins to exert its effects. The receptor has a molecular weight of approximately 37 kDa. It is expressed in a variety of tissues including the heart liver lung and immune system cells. A3AR's activity involves binding with adenosine molecules which modulates different cellular responses.
Biological function summary
This receptor mediates several processes by interacting with specific ligands. A3AR is not a part of a larger receptor complex but plays a significant role in modulating inflammation and immune response. The receptor contributes to processes like cell proliferation apoptosis and protection against tissue damage. Its activation generally promotes anti-inflammatory effects making it a target for therapeutic research.
Pathways
Many important biological activities are associated with the adenosine signaling pathway. A3AR plays an essential role in the regulation of the inflammatory response and the apoptosis pathway. Through these pathways it interacts with various proteins such as adenylyl cyclase which responds to ligand binding affecting cAMP levels in cells. The receptor's influence on immune cell function links it to other adenosine receptor subtypes.
Several conditions exhibit A3AR involvement such as rheumatoid arthritis and cancer. A3AR's anti-inflammatory and pro-apoptotic characteristics make it a point of interest for modulating immune-related disorders. Research also explores its connection with proteins like NF-κB due to their role in inflammation and cancer progression. Overall A3AR remains an active target for therapeutic strategies aiming to control these diseases.