Abcam, ab203520, Anti-PCDH11X antibody [EPR16916]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PCDH11X antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16916,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PCDH11X also known as Protocadherin 11 X-linked is a protein encoded by the PCDH11X gene. It weighs around 170 kDa. This protein is expressed mainly in the brain with higher expression in cerebral cortices and hippocampus regions. PCDH11X belongs to the protocadherin family known for their role in cell adhesion. Mechanically it facilitates cell-cell interactions supporting neuronal connectivity and synapse formation.
Biological function summary
PCDH11X plays a critical role in neuronal development and differentiation. It engages in homophilic adhesion allowing neurons to communicate and establish complex networks. PCDH11X functions within synaptic junctions and contributes to maintaining neural circuitry. It often interacts with other protocadherins and is considered part of a larger adhesion protein complex which includes cadherins known to regulate cellular architecture.
Pathways
PCDH11X takes part in neural circuitry development and synaptic plasticity pathways. Notably it participates in the Wnt signaling pathway which is essential for neuronal patterning and connectivity. PCDH11X shares interaction with proteins such as beta-catenin which link cell adhesion molecules to the actin cytoskeleton further influencing signaling pathways related to neural morphogenesis.
PCDH11X shows relevance to neurodevelopmental disorders and mental health conditions like schizophrenia. Researchers notice alterations in PCDH11X expression linked to these conditions suggesting its importance in neuropsychiatric health. Additionally it is connected to the N-cadherin protein which also associates with cognitive disorders emphasizing its role in maintaining proper neural function.