Abcam, ab203570, Anti-Sumo 3 antibody [1H9L17]

Size: 100µg
Rabbit Recombinant Monoclonal SUMO3 antibody. Suitable for Flow Cyt, WB, ICC/IF, IHC-P and reacts with Human, Mouse samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human SUMO3 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:1H9L17,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IF, Flow Cyt, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SUMO3 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P55854

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Sumo 3 also referred to as Small Ubiquitin-like Modifier 3 is a protein with a mass of approximately 11 kDa. It belongs to the SUMO family which modifies other proteins by attaching to them through a process called SUMOylation. Sumo 3 gets expressed widely in many tissues including the brain heart and skeletal muscles. It plays an important role in cellular processes such as nuclear-cytosolic transport transcriptional regulation and DNA repair.
Biological function summary
Sumo 3 functions in post-translational modification of proteins and often forms part of protein complexes. This modification can alter the protein's localization stability and activity. Sumo 3 activity influences cell cycle progression mitosis and stress response. SUMOylation including Sumo 3 adjusts protein interactions and functions impacting cellular homeostasis and modulation of transcription factors.
Pathways
Sumo 3 participates in the DNA repair and cellular stress response pathways. Through these pathways Sumo 3 closely interacts with proteins such as P53 an important protein in cell cycle regulation and apoptosis. Sumo 3 aids in facilitating DNA damage repair and protecting cells from apoptosis under stress helping maintain genomic integrity.
Sumo 3 involvement has a relation to cancer and neurodegenerative disease. Alterations in SUMOylation patterns involving Sumo 3 can lead to cancer development due to ineffective DNA repair and apoptosis. Furthermore in neurodegenerative disease Sumo 3 modulates protein aggregation processes increasing or reducing accumulation of neurotoxic proteins. Sumo 3 often interacts with proteins like huntingtin in Huntington's disease influencing disease progression through modulation of protein aggregation.