Abcam, ab203657, Anti-TSPYL5 antibody

Size: 100µL
Rabbit Polyclonal TSPYL5 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TSPYL5 aa 250-350 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TSPYL5 aa 250-350 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q86VY4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TSPYL5 protein also known as Testis-Specific Y-encoded-Like Protein 5 plays a role as a transcription regulator. It is encoded by the TSPYL5 gene and has a molecular mass of approximately 70 kDa. TSPYL5 is expressed in various human tissues with higher levels detected in the testis brain and epithelial tissues. Researchers have noted its presence in different cancer cell lines highlighting its significance in cancer research.
Biological function summary
The functions of TSPYL5 impact cellular processes including cell growth and survival. While not recognized as part of a specific protein complex TSPYL5 appears to influence transcriptional regulation by interacting with other molecular players. It shows interaction with chromatin and may modulate gene expression patterns that are important for cellular homeostasis.
Pathways
TSPYL5 integrates into pathways that regulate cellular proliferation and apoptosis. The protein plays a role within the stress-induced transcriptional regulation pathway and the cell cycle control pathway. In these contexts it can interact with other key proteins such as p53 and HDAC1 influencing the cellular response to various internal and external stimuli.
TSPYL5 has connections to cancer development especially in prostate and breast cancer. The protein might contribute to tumorigenesis by altering gene expression profiles that control cell cycle and apoptosis linking it with common oncogenes and tumor suppressors. These activities connect TSPYL5 to proteins such as p21 and RB1 which are also involved in regulating cell growth and death highlighting its role as a potential therapeutic target in cancer treatment.