Abcam, ab203663, Anti-GPCR GPR55 antibody

Size: 100µL
Rabbit Polyclonal GPCR GPR55 antibody. Suitable for Flow Cyt, WB and reacts with Mouse, Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human GPR55 aa 150-200 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GPR55 aa 150-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9Y2T6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GPR55 receptor also known as G protein-coupled receptor 55 or GPR-55 is a member of the G-protein-coupled receptor (GPCR) family. GPR55 is involved mechanically in cell signaling by interacting with ligands to activate intracellular signal transduction pathways. It has a molecular mass of approximately 37 kDa. This receptor is widely distributed in tissues including the brain spleen and gastrointestinal tract which supports its involvement in various physiological processes.
Biological function summary
GPR55 influences numerous functions such as modulation of neurotransmitter release and immune responses. Although not part of a larger receptor complex it acts independently as a signaling entity. GPR55 is involved in the regulation of blood pressure potentially influencing cardiovascular health. Its expression and activity in the central nervous system suggest roles in nervous system signaling and regulation.
Pathways
GPR55 integrates into the cannabinoid signaling pathway and can impact phosphatidylinositol-45-bisphosphate 3-kinase (PI3K) pathway. GPR55 interacts closely with other cannabinoid receptors like CB1 and CB2 although they functionally differ. This receptor's involvement provides flexibility in the signaling networks important for maintaining homeostasis and cellular responses to external stimuli.
GPR55 has associations with cancer and inflammation. Its signaling interference may contribute to tumor growth and could alter inflammatory responses. The receptor shares pathogenetic pathways with proteins such as CB1 and PI3K both of which influence oncogenic and inflammatory mechanisms. Understanding these interactions is essential for targeting GPR55 in therapeutic development for related diseases.