Abcam, ab203835, Anti-ACTR1B antibody [EPR16969]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ACTR1B antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16969,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, IHC-P, ICC/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACTR1B also known as Actin-Related Protein 1B is part of the ACTR family and plays a mechanical role in cellular processes. It has a molecular mass of approximately 45 kDa. ACTR1B expresses in various tissues including the brain and the testis. The protein is a component of the dynactin complex which associates with microtubules and is essential for dynein-mediated transport within cells.
Biological function summary
ACTR1B supports cellular activities such as intracellular transport and maintenance of cytoskeletal structure. It functions as a part of the dynactin complex a group of proteins that includes p150Glued and p50. This complex has a significant role in the function of cytoplasmic dynein a motor protein responsible for vesicle trafficking mitotic spindle organization and chromosome movement during cell division.
Pathways
ACTR1B contributes to intracellular transport and cytoskeletal regulation through its involvement in the dynactin complex. It directly participates in the dynein-dynactin pathway where it interacts with proteins like LIS1 and Ndel1 to facilitate microtubule-based movements. ACTR1B also plays a part in the endosome sorting pathway affecting proteins related to transport and sorting of intracellular cargo.
Faulty ACTR1B function can contribute to neurodegenerative diseases and developmental disorders. For example its connection to dynein pathway disruptions links ACTR1B to defects in nervous system development potentially causing intellectual disabilities and lissencephaly. The protein's role in intracellular trafficking involves it with cellular stress responses linking it to some neurodegenerative diseases through proteins like tau and huntingtin.