Abcam, ab204085, Anti-ADGB/Androglobin antibody

Size: 100µL
Rabbit Polyclonal ADGB/Androglobin antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADGB aa 550-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ADGB aa 550-700. The exact immunogen used to generate this antibody is proprietary information.Q8N7X0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Androglobin also known as ADGB is a protein with a mass of approximately 180 kDa. It has a unique structure that includes a globin domain which is less common among other globin proteins. Androglobin is expressed primarily in testis tissue but researchers have also found it in the brain and smooth muscle. This expression pattern suggests it may have specialized roles in these tissues particularly relating to its mechanical action in oxygen binding and regulation.
Biological function summary
ADGB may function as a monomer as it does not form part of a larger protein complex known so far. It seems involved in tissue development and differentiation potentially influencing processes such as sperm maturation due to its expression in testis. The presence of the globin domain might suggest a role in sensing or transferring oxygen although this specific function in ADGB is less defined compared to traditional globins like hemoglobin or myoglobin.
Pathways
The involvement of Androglobin in distinct biological pathways is not fully understood but researchers suspect it might interplay in pathways related to cellular respiration or apoptosis. In these processes proteins such as cytochrome c and caspases are important and perhaps could be influenced or regulated by ADGB's functions due to its potential oxygen-binding characteristics.
Researchers are beginning to explore connections between Androglobin and conditions such as male infertility and certain types of muscular disorders. Alterations or mutations in ADGB could impair normal sperm development or function in testicular tissues. Additionally due to its expression in smooth muscle it may relate to muscle function pathologies although conclusive evidence is still lacking. Further study could reveal links to specific proteins like FSH receptor or actin involved in these disorders.