Abcam, ab204137, Recombinant human SBK1 protein

Size: 5µg / 10µg
Recombinant human SBK1 protein is a Human Full Length protein, in the 1 to 424 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>90% Densitometry,
Expression system:Baculovirus infected Sf9 cells,
Tags:GST tag N-Terminus,
Applications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The specific activity of ab204137 was determined to be 20 nmol /min/mg.,
Accession:Q52WX2,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

Product details:
ab204874
(PKI-alpha peptide) can be utilized as a substrate for assessing kinase activity

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SBK1 also known as SH3 domain binding kinase 1 is a serine/threonine protein kinase. It measures approximately 110 kDa in mass. SBK1 expresses in various tissues including the brain and testis suggesting its involvement in multiple physiological processes. The kinase activity of SBK1 participates in phosphorylating target proteins influencing cellular functions. Researchers often study SBK1 to understand the regulation of signaling pathways in the nervous system.
Biological function summary
SBK1 plays important roles in the regulation of neuronal development and synaptic function. It often associates with protein complexes that guide cellular signaling and differentiation. The kinase activity impacts the structure and function of synapses affecting how neurons connect and communicate. By interacting with other kinases and signaling molecules SBK1 contributes to the development function and maintenance of neuronal circuits.
Pathways
SBK1 integrates into vital signaling networks including the MAPK and PI3K-Akt pathways. These pathways manage diverse cellular responses such as growth survival and differentiation. SBK1 interacts with other pathway members such as ERK1/2 in the MAPK pathway coordinating responses that control cell fate and function. By modulating these pathways SBK1 impacts key cellular processes providing insights into its broader physiological roles.
SBK1 relates to neurological conditions and certain cancers. The dysregulation of SBK1 can contribute to disorders like schizophrenia where its altered signaling affects brain function and structure. In cancer overactive SBK1-driven pathways influence cell proliferation and survival contributing to tumor development. Through these conditions SBK1 intersects with proteins like AKT indicating its significant impact in disease progression and as a potential therapeutic target.